Klotho protein and atherosclerotic cardiovascular diseases: prolonging the thread of life

To date, the most widely used biomarkers are natriuretic peptides and cardiac troponins. Many other have also been identified, but only a few of them found application in actual clinical practice. This review focuses on Klotho protein its role cardiovascular diseases.
 In 1997, gene that slows down aging process was identified. It named (Greek, ώ, spinning; Latin, Clotho; English, Klotho) honor goddess ancient Greek mythology, spinning thread life being personification steady, calm course fate. Mice with an insertional mutation region promoter were characterized by premature processes. Three families known: -Klotho, studied is -Klotho. The consists large extracellular domain short C-terminal intracellular region. two repeat sequences called KL1 KL2. -Klotho contain KL2 domains, respectively, contains domain. humans located chromosome 13q12 five exons. mainly expressed distal convoluted tubules kidneys vascular epithelial plexus cerebral ventricles. At lower concentrations, organs tissues, particularly heart.
 studies demonstrated protective pathology. pleiotropic properties this reflected diversity interaction cardioprotective mechanisms. regulation concentrations blood expression heart cells help drugs can play significant cellular metabolism represent promising target for treatment pathologies.